Ontology highlight
ABSTRACT:
SUBMITTER: Hosoi T
PROVIDER: S-EPMC6168632 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Hosoi Toru T Nakashima Mieko M Ozawa Koichiro K
Frontiers in physiology 20180926
It is known that endoplasmic reticulum (ER) and nucleus communicate with each other to cope with ER stress. However, the mechanisms through which extracellular transmission of ER stress occurs remain unexplored. When the ER stress-induced unfolded protein response (UPR) is activated, the X-box binding protein 1 (XBP1) mRNA is spliced by inositol-requiring enzyme-1α (IRE1α) to produce the spliced form of XBP1 (sXBP1). In the present study, we found that sXBP1 mRNA in the cell may be incorporated ...[more]