Ontology highlight
ABSTRACT:
SUBMITTER: Novak WRP
PROVIDER: S-EPMC6168774 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Novak Walter R P WRP West Korbin H J KHJ Kirkman Lucy M D LMD Brandt Gabriel S GS
Acta crystallographica. Section F, Structural biology communications 20180921 Pt 10
The development of antimalarial drugs remains a public health priority, and the orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum (PfOMPDC) has great potential as a drug target. The crystallization of PfOMPDC with substrate bound represents an important advance for structure-based drug-design efforts [Tokuoka et al. (2008), J. Biochem. 143, 69-78]. The complex of the enzyme bound to the substrate OMP (PDB entry 2za1) would be of particular utility in this regard. However, re-re ...[more]