Dataset Information

Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies.

ABSTRACT: Introduction:The association between interleukin-10- (IL-10-) 592 (-590, -597) C>A polymorphisms and susceptibility to chronic or aggressive periodontitis (CP or AgP) is conflicting. This meta-analysis is aimed at quantitatively estimating the association. Materials and Methods:PubMed, Embase, Web of Science, and WANFAN were searched for studies performed prior to January 31, 2018, to collect data for our research. Meta-analysis was performed using RevMan 5.3 or STATA 14.0. Results:In total, 18 studies that met our criteria were included. Overall or HWE subgroup analysis of individuals with this polymorphism revealed that in terms of CP susceptibility, there was a significant difference between case groups and control groups in the A allele versus C allele model (OR?=?1.38, 95% CI?=?1.17-1.64 or OR?=?1.38, 95% CI?=?1.12-1.70), in the AA versus CC+CA model (OR?=?1.49, 95% CI =1.06-2.10 or OR?=?1.42, 95% CI?=?1.13-1.78), and in the CC versus CA+AA model (OR?=?0.69, 95% CI?=?0.51-0.92 or OR?=?0.68, 95% CI?=?0.49-0.93); subgroup analysis based on a nonsmoking population also displayed significance in the A allele versus C allele model (OR?=?1.43, 95% CI?=?1.15-1.79) and CC versus CA+AA model (OR?=?0.62, 95% CI?=?0.44-0.87). For this polymorphisms and AgP susceptibility, our analyses revealed a significant association in both the A allele versus C allele model (OR?=?1.29, 95% CI?=?1.01-1.63) and the AA versus CC+CA model (OR?=?1.93, 95% CI?=?1.30-2.89); subgroup analysis based on Caucasian or nonsmoking populations showed significant differences in the AA versus CC+CA model (OR?=?6.29, 95% CI?=?1.78-22.21 or OR?=?3.24, 95% CI?=?1.59-6.61). Conclusions:IL-10-592 (-590, -597) A allele and the associated AA genotype may be risk factors for the onset of CP or AgP-particularly for the AA genotype and the increased risk of AgP in Caucasian or nonsmoking populations. Conversely, the CC genotype may act as a protective factor against the onset of CP.

SUBMITTER: Li Y

PROVIDER: S-EPMC6169208 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies.

Li Yao Y Feng Ge G Deng Yuejia Y Song Jinglin J

Disease markers 20180919

<h4>Introduction</h4>The association between interleukin-10- (IL-10-) 592 (-590, -597) C>A polymorphisms and susceptibility to chronic or aggressive periodontitis (CP or AgP) is conflicting. This meta-analysis is aimed at quantitatively estimating the association.<h4>Materials and methods</h4>PubMed, Embase, Web of Science, and WANFAN were searched for studies performed prior to January 31, 2018, to collect data for our research. Meta-analysis was performed using RevMan 5.3 or STATA 14.0.<h4>Res ...[more]

PMID: 30327689

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Project description:BACKGROUND:Periodontitis is a major oral health problem and it is considered as one of the reasons for tooth loss in developing and developed nations. The objective of the current review was to investigate the association between IL10 polymorphisms -?1082 A?>?G (rs1800896), -819C?>?T (rs1800871), -?592 A?>?C (rs1800872) and the risk of either chronic periodontitis or aggressive periodontitis. METHODS:This is a meta- analysis study, following the preferred reporting items for systematic reviews and meta- analyses (PRISMA). Relevant studies were searched in the health related electronic databases. Methodological quality of the included studies were assessed using the Newcastle-Ottawa Scale. For individual studies, odds ratio (OR) and its 95%confidence interval (CI) were calculated to assess the strength of association between IL10 polymorphisms (-?1082 A?>?G, -819C?>?T, -?592 A?>?C) and the risk of periodontitis. For pooling of the estimates across studies included, the summary OR and its 95% CIs were calculated with random-effects model. The pooled estimates were done under four genetic models such as the allelic contrast model, the recessive model, the dominant model and the additive model. Trial sequential analysis (TSA) was done for estimation of the required information size for this meta-analysis study. RESULTS:Sixteen studies were identified for this review. The included studies were assessed to be of moderate to good methodological quality. A significant association between polymorphism of IL10-1082 A?>?G polymorphism and the risk of chronic periodontitis in the non-Asian populations was observed only in the recessive model (OR,1.42; 95% CI:1.11, 1.8,I2: 43%). The significant associations between -?592 A?>?C polymorphism and the risk of aggressive periodontitis in the non-Asian populations were observed in particular genetic models such as allele contrast (OR, 4.34; 95%CI:1.87,10.07,I2: 65%) and recessive models (OR, 2.1; 95% CI:1.16, 3.82,I2: 0%). The TSA plot revealed that the required information size for evidence of effect was sufficient to draw a conclusion. CONCLUSIONS:This meta-analysis suggested that the IL10-1082 A?>?G polymorphism was associated with chronic periodontitis CP risk in non-Asians. Thus, in order to further establish the associations between IL10 (-?819 C?>?T, -?592 A?>?C) in Asian populations, future studies should include larger sample sizes with multi-ethnic groups.

Dataset Information

Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies.

Publications

Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies.

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