Dataset Information

Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women's Cohort Study (UKWCS).

ABSTRACT:

Objectives

Breast cancer is associated with overweight and obesity after menopause. However, clothing size as a proxy of adiposity in predicting postmenopausal breast cancer is not widely studied. We aimed to explore the relationships between postmenopausal breast cancer risk with adipose indicators (including clothing sizes) and weight change over adulthood.

Design

Prospective cohort study.

Setting

England, Wales and Scotland.

Participants

17?781 postmenopausal women from the UK Women's Cohort Study.

Primary outcome measure

Incident cases of malignant breast cancers (International Classification of Diseases (ICD) 9 code 174 and ICD 10 code C50).

Results

From 282?277 person-years follow-up, there were 946 incident breast cancer cases with an incidence rate of 3.35 per 1000 women. Body mass index (HR: 1.04; 95%?CI: 1.02 to 1.07), blouse size (HR: 1.10; 1.03 to 1.18), waist circumference (HR: 1.07; 1.01 to 1.14) and skirt size (HR: 1.14;1.06 to 1.22) had positive associations with postmenopausal breast cancer after adjustment for potential confounders. Increased weight over adulthood (HR: 1.02; 1.01 to 1.03) was also associated with increased risk for postmenopausal breast cancer.

Conclusions

Blouse and skirt sizes can be used as adipose indicators in predicting postmenopausal breast cancer. Maintaining healthy body weight over adulthood is an effective measure in the prevention of postmenopausal breast cancer.

SUBMITTER: Moy FM

PROVIDER: S-EPMC6169772 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Publications

Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women's Cohort Study (UKWCS).

Moy Foong Ming FM Greenwood Darren C DC Cade Janet E JE

BMJ open 20180928 9

<h4>Objectives</h4>Breast cancer is associated with overweight and obesity after menopause. However, clothing size as a proxy of adiposity in predicting postmenopausal breast cancer is not widely studied. We aimed to explore the relationships between postmenopausal breast cancer risk with adipose indicators (including clothing sizes) and weight change over adulthood.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>England, Wales and Scotland.<h4>Participants</h4>17 781 postmenopausal wome ...[more]

PMID: 30269068

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Dataset Information

Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women's Cohort Study (UKWCS).

Objectives

Design

Setting

Participants

Primary outcome measure

Results

Conclusions

Publications

Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women's Cohort Study (UKWCS).

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