Ontology highlight
ABSTRACT:
SUBMITTER: Beckmann N
PROVIDER: S-EPMC6173435 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Beckmann Nadine N Pugh Amanda M AM Caldwell Charles C CC
PloS one 20181005 10
Burn patients have a high risk of sepsis-related mortality even after surviving the initial injury. Immunosuppression increases the risk of sepsis after burn injury, as does the disruption of the intestinal epithelial barrier, which allows the translocation of bacteria and bacterial products into the circulation. The integrity of the intestinal epithelial barrier is largely maintained by the intestinal microbiota. Burn injury has been reported to result in significant changes in the intestinal m ...[more]