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Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents.

ABSTRACT: Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)_3-3×(NH₂trz)_3×](BF₄)₂ (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280-330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

SUBMITTER: Tsukiashi A

PROVIDER: S-EPMC6175957 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents.

Tsukiashi Asami A Min Kil Sik KS Kitayama Hikaru H Terasawa Hiroaki H Yoshinaga Sosuke S Takeda Mitsuhiro M Lindoy Leonard F LF Hayami Shinya S

Scientific reports 20181008 1

Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280-330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent. ...[more]

PMID: 30297794

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