Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6176107 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Wang Yifei Y Wang Yifei Y Sedlacek Abigail L AL Pawaria Sudesh S Xu Haiyan H Scott Melanie J MJ Binder Robert J RJ
Journal of immunology (Baltimore, Md. : 1950) 20180912 8
Several heat shock proteins (HSPs) prime immune responses, which are, in part, a result of activation of APCs. APCs respond to these immunogenic HSPs by upregulating costimulatory molecules and secreting cytokines, including IL-1β. These HSP-mediated responses are central mediators in pathological conditions ranging from cancer, sterile inflammation associated with trauma, and rheumatoid arthritis. We tested in this study the requirement of inflammasomes in the release of IL-1β by one immunogeni ...[more]