Ontology highlight
ABSTRACT:
SUBMITTER: Atif SM
PROVIDER: S-EPMC4632856 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Atif Shaikh M SM Nelsen Michelle K MK Gibbings Sophie L SL Desch A Nicole AN Kedl Ross M RM Gill Ronald G RG Marrack Philippa P Murphy Kenneth M KM Grazia Todd J TJ Henson Peter M PM Jakubzick Claudia V CV
Journal of immunology (Baltimore, Md. : 1950) 20150601 1
In transplantation, a major obstacle for graft acceptance in MHC-matched individuals is the mismatch of minor histocompatibility Ags. Minor histocompatibility Ags are peptides derived from polymorphic proteins that can be presented by APCs on MHC molecules. The APC subtype uniquely responsible for the rejection of minor Ag-mismatched grafts has not yet been identified. In this study, we examined graft rejection in three mouse models: 1) mismatch of male-specific minor Ags, 2) mismatch of minor A ...[more]