Ontology highlight
ABSTRACT:
SUBMITTER: Halbroth BR
PROVIDER: S-EPMC6177389 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Halbroth Benedict R BR Sebastian Sarah S Poyntz Hazel C HC Bregu Migena M Cottingham Matthew G MG Hill Adrian V S AVS Spencer Alexandra J AJ
Scientific reports 20181009 1
Despite promising progress in malaria vaccine development, an efficacious subunit vaccine against P. falciparum remains to be licensed and deployed. This study aimed to improve on the immunogenicity of the leading liver-stage vaccine candidate (ChAd63-MVA ME-TRAP), known to confer protection by eliciting high levels of antigen-specific CD8<sup>+</sup> T cells. We previously showed fusion of ME-TRAP to the human MHC class II invariant chain (Ii) could enhance CD8<sup>+</sup> T cell responses in n ...[more]