Unknown

Dataset Information

0

A novel cyclic peptide targeting LAG-3 for cancer immunotherapy by activating antigen-specific CD8+ T cell responses.


ABSTRACT: Graphical abstractCyclic peptide C25 targeting LAG-3 was developed by phage display bio-panning. C25 binds to LAG-3 and is capable of preventing the binding of LAG-3 to HLA-DR. C25 exhibits significant anti-tumor activity dependent on CD8+ T cells activation. Surprisingly, it can also lead to the reduction of Tregs in tumor microenvironment.Image 1

SUBMITTER: Zhai W 

PROVIDER: S-EPMC7332792 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3321869 | biostudies-other
| S-EPMC5693629 | biostudies-literature
| S-EPMC9321026 | biostudies-literature
| S-EPMC2892606 | biostudies-literature
| S-EPMC4156517 | biostudies-literature
| S-EPMC9179507 | biostudies-literature
| S-EPMC1895803 | biostudies-literature
| S-EPMC3493661 | biostudies-literature
| S-EPMC10478462 | biostudies-literature
| S-EPMC4292268 | biostudies-other