Ontology highlight
ABSTRACT:
SUBMITTER: Ruder D
PROVIDER: S-EPMC6188056 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Ruder Dennis D Papadimitrakopoulou Vassiliki V Shien Kazuhiko K Behrens Carmen C Kalhor Neda N Chen Huiqin H Shen Li L Lee J Jack JJ Hong Waun Ki WK Tang Ximing X Girard Luc L Minna John D JD Diao Lixia L Wang Jing J Mino Barbara B Villalobos Pamela P Rodriguez-Canales Jaime J Hanson Nana E NE Sun James J Miller Vincent V Greenbowe Joel J Frampton Garrett G Herbst Roy S RS Baladandayuthapani Veera V Wistuba Ignacio I II Izzo Julie G JG
Oncotarget 20180921 74
Despite a therapeutic paradigm shift into targeted-driven medicinal approaches, resistance to therapy remains a hallmark of lung cancer, driven by biological and molecular diversity. Using genomic and expression data from advanced non-small cell lung cancer (NSCLC) patients enrolled in the BATTLE-2 clinical trial, we identified <i>RICTOR</i> alterations in a subset of lung adenocarcinomas and found <i>RICTOR</i> expression to carry worse overall survival. RICTOR-altered cohort was significantly ...[more]