Dataset Information

Lower between-limb asymmetry during running on treadmill compared to overground in subjects with laterally pronounced knee osteoarthritis.

ABSTRACT: Subjects with knee osteoarthritis (KOA) show gait asymmetries evidenced by lower knee flexion and shorter contact times for the affected leg. Interestingly, running on a treadmill compared to running overground is also associated with lower knee flexion and shorter contact times. Thus, it is of particular interest how gait patterns are influenced by the type of ground in subjects with KOA. The aim of the current study was therefore to measure the overground asymmetry of kinematic parameters in KOA subjects while running and to investigate whether this asymmetry is altered on a treadmill. Nine patients diagnosed with KOA underwent overground and treadmill running with 3D-motion analysis. The symmetry analysis was performed using Symmetry Angles for five selected gait parameters: contact and step time, heel-toe delay, maximal knee flexion during stance and vertical speed variance. For all parameters, the values were significantly lower for the affected compared to the non-affected leg (p?0.023). Post-hoc analyses revealed significant differences between legs only overground and not on the treadmill. The asymmetry was lower on the treadmill, as indicated by significant Symmetry Angle reductions for contact time (p = 0.033), knee flexion (p = 0.001) and vertical speed variance (p = 0.002). The symmetry increase on the treadmill was mainly due to changes of the non-affected leg towards the affected leg values leading to smaller steps and less impact load in general. The present results suggest therefore that a) an assessment of symmetry may differ depending on the ground type (treadmill versus overground) and b) treadmill running may be more suitable for patients with KOA related gait asymmetries.

SUBMITTER: Robadey J

PROVIDER: S-EPMC6193626 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Lower between-limb asymmetry during running on treadmill compared to overground in subjects with laterally pronounced knee osteoarthritis.

Robadey Jacques J Staudenmann Didier D Schween Raphael R Gehring Dominic D Gollhofer Albert A Taube Wolfgang W

PloS one 20181018 10

Subjects with knee osteoarthritis (KOA) show gait asymmetries evidenced by lower knee flexion and shorter contact times for the affected leg. Interestingly, running on a treadmill compared to running overground is also associated with lower knee flexion and shorter contact times. Thus, it is of particular interest how gait patterns are influenced by the type of ground in subjects with KOA. The aim of the current study was therefore to measure the overground asymmetry of kinematic parameters in K ...[more]

PMID: 30335784

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Project description:BackgroundTreadmills are often used in research, clinical practice, and training. Biomechanical investigations comparing treadmill and overground running report inconsistent findings.ObjectiveThis study aimed at comparing biomechanical outcomes between motorized treadmill and overground running.MethodsFour databases were searched until June 2019. Crossover design studies comparing lower limb biomechanics during non-inclined, non-cushioned, quasi-constant-velocity motorized treadmill running with overground running in healthy humans (18-65 years) and written in English were included. Meta-analyses and meta-regressions were performed where possible.Results33 studies (n = 494 participants) were included. Most outcomes did not differ between running conditions. However, during treadmill running, sagittal foot-ground angle at footstrike (mean difference (MD) - 9.8° [95% confidence interval: - 13.1 to - 6.6]; low GRADE evidence), knee flexion range of motion from footstrike to peak during stance (MD 6.3° [4.5 to 8.2]; low), vertical displacement center of mass/pelvis (MD - 1.5 cm [- 2.7 to - 0.8]; low), and peak propulsive force (MD - 0.04 body weights [- 0.06 to - 0.02]; very low) were lower, while contact time (MD 5.0 ms [0.5 to 9.5]; low), knee flexion at footstrike (MD - 2.3° [- 3.6 to - 1.1]; low), and ankle sagittal plane internal joint moment (MD - 0.4 Nm/kg [- 0.7 to - 0.2]; low) were longer/higher, when pooled across overground surfaces. Conflicting findings were reported for amplitude of muscle activity.ConclusionsSpatiotemporal, kinematic, kinetic, muscle activity, and muscle-tendon outcome measures are largely comparable between motorized treadmill and overground running. Considerations should, however, particularly be given to sagittal plane kinematic differences at footstrike when extrapolating treadmill running biomechanics to overground running. Protocol registration CRD42018083906 (PROSPERO International Prospective Register of Systematic Reviews).

Project description:BACKGROUND:Musculoskeletal disorders can result from prolonged repetitive and/or forceful movements. Performance of an upper extremity high repetition high force task increases serum pro-inflammatory cytokines and upper extremity sensorimotor declines in a rat model of work-related musculoskeletal disorders. Since one of the most efficacious treatments for musculoskeletal pain is exercise, this study investigated the effectiveness of treadmill running in preventing these responses. METHODS:Twenty-nine young adult female Sprague-Dawley rats were used. Nineteen were trained for 5?weeks to pull a lever bar at high force (15?min/day). Thirteen went on to perform a high repetition high force reaching and lever-pulling task for 10?weeks (10-wk HRHF; 2?h/day, 3?days/wk). From this group, five were randomly selected to undergo forced treadmill running exercise (TM) during the last 6?weeks of task performance (10-wk HRHF+TM, 1?h/day, 5?days/wk). Results were compared to 10 control rats and 6 rats that underwent 6?weeks of treadmill running following training only (TR-then-TM). Voluntary task and reflexive sensorimotor behavioral outcomes were assessed. Serum was assayed for inflammatory cytokines and corticosterone, reach limb median nerves for CD68+ macrophages and extraneural thickening, and reach limb flexor digitorum muscles and tendons for pathological changes. RESULTS:10-wk HRHF rats had higher serum levels of IL-1?, IL-1? and TNF?, than control rats. In the 10-wk HRHF+TM group, IL-1? and TNF? were lower, whereas IL-10 and corticosterone were higher, compared to 10-wk HRHF only rats. Unexpectedly, several voluntary task performance outcomes (grasp force, reach success, and participation) worsened in rats that underwent treadmill running, compared to untreated 10-wk HRHF rats. Examination of forelimb tissues revealed lower cellularity within the flexor digitorum epitendon but higher numbers of CD68+ macrophages within and extraneural fibrosis around median nerves in 10-wk HRHF+TM than 10-wk HRHF rats. CONCLUSIONS:Treadmill running was associated with lower systemic inflammation and moderate tendinosis, yet higher median nerve inflammation/fibrosis and worse task performance and sensorimotor behaviors. Continued loading of the injured tissues in addition to stress-related factors associated with forced running/exercise likely contributed to our findings.

Dataset Information

Lower between-limb asymmetry during running on treadmill compared to overground in subjects with laterally pronounced knee osteoarthritis.

Publications

Lower between-limb asymmetry during running on treadmill compared to overground in subjects with laterally pronounced knee osteoarthritis.

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