Ontology highlight
ABSTRACT:
SUBMITTER: Zanetti-Domingues LC
PROVIDER: S-EPMC6193980 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zanetti-Domingues Laura C LC Korovesis Dimitrios D Needham Sarah R SR Tynan Christopher J CJ Sagawa Shiori S Roberts Selene K SK Kuzmanic Antonija A Ortiz-Zapater Elena E Jain Purvi P Roovers Rob C RC Lajevardipour Alireza A van Bergen En Henegouwen Paul M P PMP Santis George G Clayton Andrew H A AHA Clarke David T DT Gervasio Francesco L FL Shan Yibing Y Shaw David E DE Rolfe Daniel J DJ Parker Peter J PJ Martin-Fernandez Marisa L ML
Nature communications 20181018 1
Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is based on X-ray structural data of monomer and dimer receptor fragments and does not explain how mutations achieve ligand-independent phosphorylation. Using a repertoire of imaging technologies and simulations we reveal an extracellular head-to-head interaction through which ligand-free receptor polymer chains of various lengths assemble. The architecture of the head-to-head interaction prevents kinase-mediated ...[more]