Glaulactams A-C, daphniphyllum alkaloids from Daphniphyllum glaucescens.
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ABSTRACT: Glaulactams A-C (1-3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.
SUBMITTER: Chao CH
PROVIDER: S-EPMC6193994 | biostudies-literature |
REPOSITORIES: biostudies-literature
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