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Five new alkaloids from the stem bark of Daphniphyllum macropodum.

ABSTRACT: Five new alkaloids, daphnicyclidins M and N (compounds 1 and 2) and calyciphyllines Q-S (compounds 3-5), along with four known ones, paxiphylline C (6), macropodumine B (7), macropodumine C (8) and daphnicyclidin A (9) were isolated from the stem bark of Daphniphyllum macropodum. Calyciphylline Q (3) is the first calyciphylline A derivative possessing a double bond between C-18 and C-19. Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especially 2D NMR techniques. Compounds 1, 2, 8 and 9 exhibited cytotoxic activity against P-388 cells with IC?? values of 5.7, 6.5, 10.3 and 13.8 µM, respectively. Compounds 1 and 2 also showed cytotoxic activity against SGC-7901 cells with IC?? values of 22.4 and 25.6 µM.

SUBMITTER: Lu Y

PROVIDER: S-EPMC6271962 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Five new alkaloids from the stem bark of Daphniphyllum macropodum.

Lu Yunyang Y Gao Kai K Wang Xiaoyang X Zhang Wei W Ma Ning N Tang Haifeng H

Molecules (Basel, Switzerland) 20140310 3

Five new alkaloids, daphnicyclidins M and N (compounds 1 and 2) and calyciphyllines Q-S (compounds 3-5), along with four known ones, paxiphylline C (6), macropodumine B (7), macropodumine C (8) and daphnicyclidin A (9) were isolated from the stem bark of Daphniphyllum macropodum. Calyciphylline Q (3) is the first calyciphylline A derivative possessing a double bond between C-18 and C-19. Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especiall ...[more]

PMID: 24619303

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