Ontology highlight
ABSTRACT:
SUBMITTER: Radulovic M
PROVIDER: S-EPMC6213280 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Radulovic Maja M Schink Kay O KO Wenzel Eva M EM Nähse Viola V Bongiovanni Antonino A Lafont Frank F Stenmark Harald H
The EMBO journal 20181012 21
Although lysosomes perform a number of essential cellular functions, damaged lysosomes represent a potential hazard to the cell. Such lysosomes are therefore engulfed by autophagic membranes in the process known as lysophagy, which is initiated by recognition of luminal glycoprotein domains by cytosolic lectins such as Galectin-3. Here, we show that, under various conditions that cause injury to the lysosome membrane, components of the endosomal sorting complex required for transport (ESCRT)-I, ...[more]