Ontology highlight
ABSTRACT:
SUBMITTER: Fekry B
PROVIDER: S-EPMC6195513 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature communications 20181019 1
Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of liver-specific gene expression with potent tumor suppressor activity, yet many liver tumors express HNF4α. This study reveals that P1-HNF4α, the predominant isoform expressed in the adult liver, inhibits expression of tumor promoting genes in a circadian manner. In contrast, an additional isoform of HNF4α, driven by an alternative promoter (P2-HNF4α), is induced in HNF4α-positive human hepatocellular carcinoma (HCC). P2-HNF4α rep ...[more]