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Association between early antibiotic exposure and bronchopulmonary dysplasia or death.

ABSTRACT: OBJECTIVE:To characterize the independent association between antibiotic exposure in the first week of life and the risk of bronchopulmonary dysplasia (BPD) or death among very preterm infants without culture-confirmed sepsis. METHODS:Retrospective cohort study using the Optum Neonatal Database. Infants without culture-confirmed sepsis born less than 1500?g and less than 32 weeks gestation between 1/2010 and 11/2016 were included. The independent association between antibiotic therapy during the first week of life and BPD or death prior to 36 weeks postmenstrual age (PMA) was assessed by multivariable logistic regression. RESULTS:Of 4950 infants, 3946 (79.7%) received antibiotics during the first week of life. Rates of BPD or death (41.5% vs. 31.1%, p?

SUBMITTER: Flannery DD

PROVIDER: S-EPMC6195849 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Association between early antibiotic exposure and bronchopulmonary dysplasia or death.

Flannery Dustin D DD Dysart Kevin K Cook Alison A Greenspan Jay J Aghai Zubair H ZH Jensen Erik A EA

Journal of perinatology : official journal of the California Perinatal Association 20180613 9

<h4>Objective</h4>To characterize the independent association between antibiotic exposure in the first week of life and the risk of bronchopulmonary dysplasia (BPD) or death among very preterm infants without culture-confirmed sepsis.<h4>Methods</h4>Retrospective cohort study using the Optum Neonatal Database. Infants without culture-confirmed sepsis born less than 1500 g and less than 32 weeks gestation between 1/2010 and 11/2016 were included. The independent association between antibiotic the ...[more]

PMID: 29895965

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