3'-Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease.
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ABSTRACT:
SUBMITTER: Thompson WJ
PROVIDER: S-EPMC6196357 | biostudies-literature | 1993 Jan
REPOSITORIES: biostudies-literature
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3'-Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease.
Thompson Wayne J WJ Ghosh Arun K AK Holloway M Katharine MK Lee Hee Yoon HY Munson Peter M PM Schwering John E JE Wai Jenny J Darke Paul L PL Zugay Joan J Emini Emilio A EA Schleif William A WA Huff Joel R JR Anderson Paul S PS
Journal of the American Chemical Society 19930101 2
The blockade of the HIV protease has become a major target in the search for an effective therapy for AIDS.<sup>1</sup> While many reports of potent HIV-1 inhibitors have appeared recently, the compound Ro 31-8959 remains the least selective for the HIV-1 and HIV-2 proteases.<sup>2</sup> This property may result in reduced susceptibility to resistance since these represent the genetically most divergent strains of HIV presently known to exist. ...[more]
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