Ontology highlight
ABSTRACT:
SUBMITTER: Clemmensen C
PROVIDER: S-EPMC6199300 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Clemmensen Christoffer C Jall Sigrid S Kleinert Maximilian M Quarta Carmelo C Gruber Tim T Reber Josefine J Sachs Stephan S Fischer Katrin K Feuchtinger Annette A Karlas Angelos A Simonds Stephanie E SE Grandl Gerald G Loher Daniela D Sanchez-Quant Eva E Keipert Susanne S Jastroch Martin M Hofmann Susanna M SM Nascimento Emmani B M EBM Schrauwen Patrick P Ntziachristos Vasilis V Cowley Michael A MA Finan Brian B Müller Timo D TD Tschöp Matthias H MH
Nature communications 20181023 1
Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity strategy. Here, we report that pharmacological activation of the cold receptor transient receptor potential cation channel subfamily M member 8 (TRPM8) with agonist icilin mimics the metabolic benefits of cold exposure. In diet-induced obese (DIO) mice, treatment with icilin enhances energy expenditure, and decreases body weight, without a ...[more]