Ontology highlight
ABSTRACT:
SUBMITTER: Sha SC
PROVIDER: S-EPMC6200331 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20180919 39
A method to directly arylate toluene derivatives with aryl bromides to generate diarylmethanes, which are important building blocks in drug discovery, is described. In this method, KN(SiMe<sub>3</sub>)<sub>2</sub> in combination with a (NIXANTPHOS)Pd catalyst accomplished the deprotonative activation of toluene derivatives to permit cross-coupling with aryl bromides. Good to excellent yields are obtained with a range of electron-rich to neutral aryl bromides. Both electron-rich and electron-poor ...[more]