Unknown

Dataset Information

0

Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones.


ABSTRACT: A series of propargylamides containing an electron-rich benzene ring was prepared through the Ugi reaction of 3,5-dimethoxyaniline with various propiolic acids, aldehydes and isocyanides. Subjecting these adducts to a gold-catalyzed intramolecular alkyne hydroarylation process allowed to efficiently construct the 2-quinolone core bearing a branched substituent on the nitrogen atom.

SUBMITTER: Du X 

PROVIDER: S-EPMC6204774 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones.

Du Xiaochen X   Huang Jianjun J   Nechaev Anton A AA   Yao Ruwei R   Gong Jing J   Van der Eycken Erik V EV   Pereshivko Olga P OP   Peshkov Vsevolod A VA  

Beilstein journal of organic chemistry 20181004


A series of propargylamides containing an electron-rich benzene ring was prepared through the Ugi reaction of 3,5-dimethoxyaniline with various propiolic acids, aldehydes and isocyanides. Subjecting these adducts to a gold-catalyzed intramolecular alkyne hydroarylation process allowed to efficiently construct the 2-quinolone core bearing a branched substituent on the nitrogen atom. ...[more]

Similar Datasets

| S-EPMC3817510 | biostudies-literature
| S-EPMC3389741 | biostudies-literature
| S-EPMC2924810 | biostudies-literature
| S-EPMC11002825 | biostudies-literature
| S-EPMC3252853 | biostudies-literature
| S-EPMC4251731 | biostudies-literature
| S-EPMC5950834 | biostudies-other
| S-EPMC6240703 | biostudies-literature
| S-EPMC3983127 | biostudies-other
| S-EPMC8199670 | biostudies-literature