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Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones.

ABSTRACT: A series of propargylamides containing an electron-rich benzene ring was prepared through the Ugi reaction of 3,5-dimethoxyaniline with various propiolic acids, aldehydes and isocyanides. Subjecting these adducts to a gold-catalyzed intramolecular alkyne hydroarylation process allowed to efficiently construct the 2-quinolone core bearing a branched substituent on the nitrogen atom.

SUBMITTER: Du X

PROVIDER: S-EPMC6204774 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones.

Du Xiaochen X Huang Jianjun J Nechaev Anton A AA Yao Ruwei R Gong Jing J Van der Eycken Erik V EV Pereshivko Olga P OP Peshkov Vsevolod A VA

Beilstein journal of organic chemistry 20181004

A series of propargylamides containing an electron-rich benzene ring was prepared through the Ugi reaction of 3,5-dimethoxyaniline with various propiolic acids, aldehydes and isocyanides. Subjecting these adducts to a gold-catalyzed intramolecular alkyne hydroarylation process allowed to efficiently construct the 2-quinolone core bearing a branched substituent on the nitrogen atom. ...[more]

PMID: 30410618

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