Ontology highlight
ABSTRACT:
SUBMITTER: Liu STH
PROVIDER: S-EPMC6205383 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Liu Sean T H STH Behzadi Mohammad Amin MA Sun Weina W Freyn Alec W AW Liu Wen-Chun WC Broecker Felix F Albrecht Randy A RA Bouvier Nicole M NM Simon Viviana V Nachbagauer Raffael R Krammer Florian F Palese Peter P
The Journal of clinical investigation 20181008 11
Hemagglutination inhibition (HI) titers are a major correlate of protection for influenza-related illness. The influenza virus hemagglutinin possesses antigenic sites that are the targets of HI active antibodies. Here, a panel of mutant viruses each lacking a classically defined antigenic site was created to compare the species-specific immunodominance of the antigenic sites in a clinically relevant hemagglutinin. HI active antibodies of antisera from influenza virus-infected mice targeted sites ...[more]