Ontology highlight
ABSTRACT:
SUBMITTER: Champroux A
PROVIDER: S-EPMC6210505 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Champroux Alexandre A Damon-Soubeyrand Christelle C Goubely Chantal C Bravard Stephanie S Henry-Berger Joelle J Guiton Rachel R Saez Fabrice F Drevet Joel J Kocer Ayhan A
Genes 20181017 10
Recent studies have revealed a well-defined higher order of chromosome architecture, named chromosome territories, in the human sperm nuclei. The purpose of this work was, first, to investigate the topology of a selected number of chromosomes in murine sperm; second, to evaluate whether sperm DNA damage has any consequence on chromosome architecture. Using fluorescence in situ hybridization, confocal microscopy, and 3D-reconstruction approaches we demonstrate that chromosome positioning in the m ...[more]