Ontology highlight
ABSTRACT:
SUBMITTER: Ren J
PROVIDER: S-EPMC6210917 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ren Jihui J Saied Essa M EM Zhong Aaron A Snider Justin J Ruiz Christian C Arenz Christoph C Obeid Lina M LM Girnun Geoffrey D GD Hannun Yusuf A YA
Journal of lipid research 20180828 11
The generation of most sphingolipids (SPLs) starts with condensation between serine and an activated long-chain fatty acid catalyzed by serine palmitoyltransferase (SPT). SPT can also use other amino acids to generate small quantities of noncanonical SPLs. The balance between serine-derived and noncanonical SPLs is pivotal; for example, hereditary sensory and autonomic neuropathy type I results from SPT mutations that cause an abnormal accumulation of alanine-derived SPLs. The regulatory mechani ...[more]