Dataset Information

Brief Report: Exercise and Anxiety in Adults with Arthritis and Other Rheumatic Diseases: Support for Evidential Value.

ABSTRACT:

Objective

Given the high prevalence of anxiety in adults with arthritis and other rheumatic diseases (AORD) and the subsequent need for interventions to reduce anxiety, this brief report sought to determine if evidential value exists to support the role of exercise for reducing anxiety in adults with AORD.

Methods

Utilizing data from a prior meta-analysis, a recently developed approach, P-curve, was used to determine evidential value by assessing for publication bias and p-hacking. Binomial tests as well as the more robust Stouffer's test were used to examine for evidential value. To examine the influence of selected studies on p-curve results, findings were also examined by dropping the highest and lowest p values from the analysis.

Results

The binomial test for evidential value was not statistically significant (p = 0.11) while the more robust Stouffer's test satisfied both conditions for evidential value (p = 0.002). Power analyses suggested a good fit for the observed p-curve. Results were generally robust when the least and most extreme values were excluded.

Conclusions

The results of this study provide evidential support for the benefits of exercise on anxiety in adults with AORD.

SUBMITTER: Kelley GA

PROVIDER: S-EPMC6211156 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Brief Report: Exercise and Anxiety in Adults with Arthritis and Other Rheumatic Diseases: Support for Evidential Value.

Kelley George A GA Kelley Kristi S KS Callahan Leigh F LF

BioMed research international 20181018

<h4>Objective</h4>Given the high prevalence of anxiety in adults with arthritis and other rheumatic diseases (AORD) and the subsequent need for interventions to reduce anxiety, this brief report sought to determine if evidential value exists to support the role of exercise for reducing anxiety in adults with AORD.<h4>Methods</h4>Utilizing data from a prior meta-analysis, a recently developed approach, <i>P</i>-curve, was used to determine evidential value by assessing for publication bias and <i ...[more]

PMID: 30420959

Similar Datasets

Project description:BACKGROUND/PURPOSE:Given conflicting findings, the purpose of this study was to use the meta-analytic approach to examine the effects of exercise (aerobic, strength training or both) on anxiety in adults with arthritis and other rheumatic diseases (AORD). METHODS:Randomised controlled exercise intervention trials ?4weeks in adults ?18 years of age with osteoarthritis, rheumatoid arthritis or fibromyalgia were included. Studies were located by searching eight electronic databases, cross-referencing and expert review. Dual selection and data abstraction of studies were performed. Hedge's standardised effect size (ES) was calculated for each result and pooled using the recently developed inverse heterogeneity model. Two-tailed z-alpha values ?0.05 and non-overlapping 95% CI were considered statistically significant. Heterogeneity was estimated using Q and I2 with alpha values ?0.10 for Q considered statistically significant. Small-study effects were examined using funnel plots and Egger's regression test. In addition, the number needed to treat (NNT), percentile improvement and meta-regression were conducted. RESULTS:Of the 639 citations screened, 14 studies representing 926 initially enrolled participants (539 exercise, 387 control) met the criteria for inclusion. Length of training (mean±SD) averaged 15.8±6.7 weeks, frequency 3.3±1.3 times per week and duration 28.8±14.3?min per session. Overall, statistically significant reductions in anxiety were found (exercise minus control changes ES=-0.40, 95%?CI -0.65 to -0.15, tau2=0.14; Q=40.3, P=0.0004; I2 =62.8%). The NNT was 6 with a percentile improvement of 15.5% and an estimated 5.3?million inactive US adults with AORD improving their anxiety if they started exercising regularly. Statistically significant small-study effects were observed (P<0.0001). CONCLUSIONS:Exercise is associated with reductions in anxiety among adults with selected types of AORD. However, a need exists for additional, well-designed, randomised controlled trials on this topic. PROSPERO REGISTRATION NUMBER:CRD42016048728.

Project description:Background/Objectives:Raised blood pressure is a major problem in older adults. Using a random-effects model, a recent meta-analysis reported statistically significant reductions in both resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) as a result of aerobic, resistance, and combined aerobic and resistance exercise in adults ?65 years. To provide more objective information regarding this nonpharmacologic approach, this study applied more robust methods to this data. Design:Meta-analysis of 41 randomized controlled trials representing 96 groups (52 exercise; 44 control). Setting:Any location where a randomized controlled trial could be conducted. Participants:Adults ?65 years. Intervention:Trials ?2 weeks that included aerobic, resistance, and/or combined aerobic and resistance exercise as the intervention. Measurements:The recently developed inverse heterogeneity model (IVhet) was used to pool findings and the Doi plot was used to examine for small-study effects. Absolute and relative differences between the IVhet and random-effects model were also calculated. Data were reported using the mean difference (exercise minus control) with nonoverlapping 95% confidence intervals considered statistically significant. Results:Statistically significant reductions in resting blood pressure were found as a result of aerobic exercise (SBP, -4.7 mmHg, 95% CI, -7.7 to -1.8; DBP, -2.0 mmHg, 95% CI -3.13 to -0.9), SBP but not DBP for resistance training (SBP, -7.0 mmHg, 95% CI, -10.5 to -3.4; DBP, -1.2 mmHg, 95% CI -2.7 to 0.3), and both SBP and DBP for combined aerobic and resistance training (SBP, -5.5 mmHg, 95% CI, -8.3 to -2.7; DBP, -3.7 mmHg, 95% CI -4.8 to -2.7). Conclusions:Exclusive of changes in DBP congruent with resistance training, exercise (aerobic, resistance, and combined aerobic and resistance) reduces resting SBP and DBP in older adults. These findings have practical implications when considering exercise for the prevention and treatment of raised blood pressure in older adults.

Dataset Information

Brief Report: Exercise and Anxiety in Adults with Arthritis and Other Rheumatic Diseases: Support for Evidential Value.

Objective

Methods

Results

Conclusions

Publications

Brief Report: Exercise and Anxiety in Adults with Arthritis and Other Rheumatic Diseases: Support for Evidential Value.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure