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Chrysoxanthones A?C, Three New Xanthone?Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor.


ABSTRACT: By treating with histone-deacetylase inhibitor valproate sodium, three new heterdimeric tetrahydroxanthone?chromanone lactones chrysoxanthones A?C (1?3), along with 17 known compounds were isolated from a sponge-associated Penicillium chrysogenum HLS111. The planar structures of chrysoxanthones A?C were elucidated by means of spectroscopic analyses, including MS, 1D, and 2D NMR. Their absolute configurations were established by electronic circular dichroism (ECD) calculations. Chrysoxanthones A?C exhibited moderate antibacterial activities against Bacillus subtilis with minimum inhibitory concentration (MIC) values of 5?10 ?g/mL.

SUBMITTER: Zhen X 

PROVIDER: S-EPMC6213349 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Chrysoxanthones A⁻C, Three New Xanthone⁻Chromanone Heterdimers from Sponge-Associated <i>Penicillium chrysogenum</i> HLS111 Treated with Histone Deacetylase Inhibitor.

Zhen Xin X   Gong Ting T   Wen Yan-Hua YH   Yan Dao-Jiang DJ   Chen Jing-Jing JJ   Zhu Ping P  

Marine drugs 20181001 10


By treating with histone-deacetylase inhibitor valproate sodium, three new heterdimeric tetrahydroxanthone⁻chromanone lactones chrysoxanthones A⁻C (<b>1</b>⁻<b>3</b>), along with 17 known compounds were isolated from a sponge-associated <i>Penicillium chrysogenum</i> HLS111. The planar structures of chrysoxanthones A⁻C were elucidated by means of spectroscopic analyses, including MS, 1D, and 2D NMR. Their absolute configurations were established by electronic circular dichroism (ECD) calculation  ...[more]

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