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Chrysoxanthones A?C, Three New Xanthone?Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor.

ABSTRACT: By treating with histone-deacetylase inhibitor valproate sodium, three new heterdimeric tetrahydroxanthone?chromanone lactones chrysoxanthones A?C (1?3), along with 17 known compounds were isolated from a sponge-associated Penicillium chrysogenum HLS111. The planar structures of chrysoxanthones A?C were elucidated by means of spectroscopic analyses, including MS, 1D, and 2D NMR. Their absolute configurations were established by electronic circular dichroism (ECD) calculations. Chrysoxanthones A?C exhibited moderate antibacterial activities against Bacillus subtilis with minimum inhibitory concentration (MIC) values of 5?10 ?g/mL.

SUBMITTER: Zhen X

PROVIDER: S-EPMC6213349 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Chrysoxanthones A⁻C, Three New Xanthone⁻Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor.

Zhen Xin X Gong Ting T Wen Yan-Hua YH Yan Dao-Jiang DJ Chen Jing-Jing JJ Zhu Ping P

Marine drugs 20181001 10

By treating with histone-deacetylase inhibitor valproate sodium, three new heterdimeric tetrahydroxanthone⁻chromanone lactones chrysoxanthones A⁻C (1⁻3), along with 17 known compounds were isolated from a sponge-associated Penicillium chrysogenum HLS111. The planar structures of chrysoxanthones A⁻C were elucidated by means of spectroscopic analyses, including MS, 1D, and 2D NMR. Their absolute configurations were established by electronic circular dichroism (ECD) calculation ...[more]

PMID: 30275353

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Chrysoxanthones A?C, Three New Xanthone?Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor.

Publications

Chrysoxanthones A⁻C, Three New Xanthone⁻Chromanone Heterdimers from Sponge-Associated <i>Penicillium chrysogenum</i> HLS111 Treated with Histone Deacetylase Inhibitor.

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