Ontology highlight
ABSTRACT:
SUBMITTER: Anguiano-Zarate SS
PROVIDER: S-EPMC6217725 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Anguiano-Zarate Stephanie S SS Matchett William E WE Nehete Pramod N PN Sastry Jagannadha K JK Marzi Andrea A Barry Michael A MA
The Journal of infectious diseases 20181101 12
Recent West African Ebola virus (EBOV) epidemics have led to testing different anti-EBOV vaccines, including a replication-defective adenovirus (RD-Ad) vector (ChAd3-EBOV) and an infectious, replication-competent recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (rVSV-EBOV; also known as rVSV-ZEBOV). While RD-Ads elicit protection, when scaled up to human trials, the level of protection may be much lower than that of vaccines containing viruses that can replicate. Although ...[more]