Ontology highlight
ABSTRACT:
SUBMITTER: Metzis V
PROVIDER: S-EPMC6218657 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cell 20181018 4
Neural induction in vertebrates generates a CNS that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially induced with anterior (forebrain) identity; caudalizing signals then convert a proportion to posterior fates (spinal cord). To test this model, we used chromatin accessibility to define how cells adopt region-specific neural fates. Together with genetic and biochemical perturbations, this identified a developmental time window in which genome- ...[more]