Ontology highlight
ABSTRACT:
SUBMITTER: Marcos E
PROVIDER: S-EPMC6219906 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20181029 11
β-sheet proteins carry out critical functions in biology, and hence are attractive scaffolds for computational protein design. Despite this potential, de novo design of all-β-sheet proteins from first principles lags far behind the design of all-α or mixed-αβ domains owing to their non-local nature and the tendency of exposed β-strand edges to aggregate. Through study of loops connecting unpaired β-strands (β-arches), we have identified a series of structural relationships between loop geometry, ...[more]