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Making progress in a rare disease: emerging therapeutics in soft tissue sarcomas.

ABSTRACT: Sarcomas are rare tumors derived from mesenchymal connective tissues in the body. Because there are well over 50 histologic sarcoma subtypes, including malignant and non-malignant pathologies, clinical courses and therapeutic management are widely divergent. In general, therapeutic options across all soft tissue sarcomas are limited in number and are often generalized across multiple sarcoma histologies. The recent emergence of molecularly targeted therapies and immune-based agents presents a future of refined systemic treatment practices that are rationally tailored to the tumor by histologic subtype and biologic mechanisms.

SUBMITTER: Choe J 

PROVIDER: S-EPMC6221061 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Making progress in a rare disease: emerging therapeutics in soft tissue sarcomas.

Choe Jennifer J   Riedel Richard R  

F1000Research 20181102

Sarcomas are rare tumors derived from mesenchymal connective tissues in the body. Because there are well over 50 histologic sarcoma subtypes, including malignant and non-malignant pathologies, clinical courses and therapeutic management are widely divergent. In general, therapeutic options across all soft tissue sarcomas are limited in number and are often generalized across multiple sarcoma histologies. The recent emergence of molecularly targeted therapies and immune-based agents presents a fu  ...[more]

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