Ontology highlight
ABSTRACT:
SUBMITTER: Gumbo M
PROVIDER: S-EPMC6222898 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20180815 8
Due to the increased interest in their application in the treatment of infectious diseases, boron-containing compounds have received a significant coverage in the literature. Herein, a small set of novel cinnamoly-oxaborole amides were synthesized and screened against nagana <i>Trypanosoma brucei brucei</i> for antitrypanosomal activity. Compound <b>5g</b> emerged as a new hit with an in vitro IC<sub>50</sub> value of 0.086 μM against <i>T. b. brucei</i> without obvious inhibitory activity again ...[more]