Ontology highlight
ABSTRACT:
SUBMITTER: Surendran RP
PROVIDER: S-EPMC6224034 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Surendran R Preethi RP Udayyapan Shanti D SD Clemente-Postigo Mercedes M Havik Stefan R SR Schimmel Alinda W M AWM Tinahones Fransisco F Nieuwdorp Max M Dallinga-Thie Geesje M GM
PloS one 20181108 11
GPIHBP1 is a protein localized at the endothelial cell surface that facilitates triglyceride (TG) lipolysis by binding lipoprotein lipase (LPL). Whether Glycosyl Phosphatidyl Inositol high density lipoprotein binding protein 1 (GPIHBP1) function is impaired and may underlie the hyperTG phenotype observed in type 2 diabetes is not yet established. To elucidate the mechanism underlying impaired TG homeostasis in insulin resistance state we studied the effect of insulin on GPIHBP1 protein expressio ...[more]