Ontology highlight
ABSTRACT:
SUBMITTER: Capdevila DA
PROVIDER: S-EPMC6224198 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
eLife 20181017
MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals. Although specific features of MarR family function have been described, the role of atomic motions in MarRs remains unexplored thus limiting insights into the evolution of allostery in this ubiquitous family of repressors. Here, we provide the first experimental evidence that internal dynamics play a crucial functional role in MarR ...[more]