BCL-2 inhibition in AML: an unexpected bonus?
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ABSTRACT:
SUBMITTER: Konopleva M
PROVIDER: S-EPMC6235069 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
B-cell lymphoma 2 (BCL-2) was discovered at the breakpoint of the t(14;18) in follicular lymphoma >30 years ago. Although inhibition of BCL-2 first proved valuable in lymphoid malignancies, clinical progress in myeloid malignancies lagged. Here, we summarize the basic biology and preclinical results that spurred clinical BCL-2 inhibition in acute myeloid leukemia (AML). Response rates and toxicity for venetoclax in combination with standard AML agents, such as azacitidine, decitabine, and low-do ...[more]
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