Ontology highlight
ABSTRACT:
SUBMITTER: Ganesan M
PROVIDER: S-EPMC6235802 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ganesan Murali M Poluektova Larisa Y LY Kharbanda Kusum K KK Osna Natalia A NA
World journal of gastroenterology 20181101 42
Liver injury is a characteristic feature of human immunodeficiency virus (HIV) infection, which is the second most common cause of mortality in HIV-infected patients. Now it is recognized that liver plays a key role in HIV infection pathogenesis. Antiretroviral therapy (ART), which suppresses HIV infection in permissive immune cells, is less effective in hepatocytes, thereby making these cells a silent reservoir of HIV infection. In addition to direct hepatotoxic effects of HIV, certain ART trea ...[more]