Ontology highlight
ABSTRACT:
SUBMITTER: Diaz LR
PROVIDER: S-EPMC6237222 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Díaz Laura R LR Saavedra-López Elena E Romarate Leire L Mitxitorena Izaskun I Casanova Paola V PV Cribaro George P GP Gallego José M JM Pérez-Vallés Ana A Forteza-Vila Jerónimo J Alfaro-Cervello Clara C García-Verdugo José M JM Barcia Carlos C Barcia Carlos C
JCI insight 20180920 18
Since the proper activation of T cells requires the physical interaction with target cells through the formation of immunological synapses (IS), an alteration at this level could be a reason why tumors escape the immune response. As part of their life cycle, it is thought that T cells alternate between a static phase, the IS, and a dynamic phase, the immunological kinapse (IK), depending on high or low antigen sensing. Our investigation performed in tissue samples of human glioma shows that T ce ...[more]