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Antiplasmodial flavanones and a stilbene from Carpha glomerata.

ABSTRACT: Bioassay-guided fractionation of an extract of Carpha glomerata (Cyperaceae) led to the isolation of seven compounds. Compounds 1 (carphorin A), 3 (carphorin C), 4 (carphorin D), and 5 (carphabene) are new compounds, and compound 2 (8-(3?-hydroxyisoamyl)-naringenin) was isolated for the first time as a natural product. All structures were elucidated based on analyses of their HR-ESIMS and 1D and 2D NMR data. Compounds 1, 2, and 6, which have prenyl or hydroxyprenyl side chains, exhibited antiplasmodial activities with IC50 values of 5.2?±?0.6, 3.4?±?0.4, and 6.7?±?0.8?µM against the drug-resistant Dd2 strain of Plasmodium falciparum. In addition the prenylated stilbene 5 also showed good activity, with IC50 5.8?±?0.7?µM.

SUBMITTER: Cho N

PROVIDER: S-EPMC6246035 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Antiplasmodial flavanones and a stilbene from Carpha glomerata.

Cho Namki N Valenciano Ana Lisa AL Du Yongle Y Clement Jason J Cassera Maria B MB Goetz Michael M Kingston David G I DGI

Bioorganic & medicinal chemistry letters 20180904 20

Bioassay-guided fractionation of an extract of Carpha glomerata (Cyperaceae) led to the isolation of seven compounds. Compounds 1 (carphorin A), 3 (carphorin C), 4 (carphorin D), and 5 (carphabene) are new compounds, and compound 2 (8-(3″-hydroxyisoamyl)-naringenin) was isolated for the first time as a natural product. All structures were elucidated based on analyses of their HR-ESIMS and 1D and 2D NMR data. Compounds 1, 2, and 6, which have prenyl or hydroxyprenyl side chains, exhibited antipla ...[more]

PMID: 30219526

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