Ontology highlight
ABSTRACT:
SUBMITTER: Cagigi A
PROVIDER: S-EPMC6249595 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cagigi Alberto A Ploquin Aurélie A Niezold Thomas T Zhou Yan Y Tsybovsky Yaroslav Y Misasi John J Sullivan Nancy J NJ
The Journal of infectious diseases 20181101 suppl_5
The membrane-proximal external regions (MPER) of the human immunodeficiency virus envelope glycoprotein (GP) generate broadly reactive antibody responses and are the focus of vaccine development efforts. The conservation of amino acids within filovirus GP heptad repeat region (HR)2/MPER suggests that it may also represent a target for a pan-filovirus vaccine. We immunized a cynomolgus macaque against Ebola virus (EBOV) using a deoxyribonucleic acid/adenovirus 5 prime/boost strategy, sequenced me ...[more]