Ontology highlight
ABSTRACT:
SUBMITTER: Monaghan-Benson E
PROVIDER: S-EPMC6249798 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Monaghan-Benson Elizabeth E Wittchen Erika S ES Doerschuk Claire M CM Burridge Keith K
Molecular biology of the cell 20180711 18
Idiopathic pulmonary fibrosis (IPF) is an incurable disease of the lung that is characterized by excessive deposition of extracellular matrix (ECM), resulting in disruption of normal lung function. The signals regulating fibrosis include both transforming growth factor beta (TGF-β) and tissue rigidity and a major signaling pathway implicated in fibrosis involves activation of the GTPase RhoA. During studies exploring how elevated RhoA activity is sustained in IPF, we discovered that not only is ...[more]