Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC6256369 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Yu Jinha J Mannes Philip P Jung Young-Hwan YH Ciancetta Antonella A Bitant Amelia A Lieberman David I DI Khaznadar Sami S Auchampach John A JA Gao Zhan-Guo ZG Jacobson Kenneth A KA
MedChemComm 20181018 11
Recognition of nucleosides at adenosine receptors (ARs) is supported by multiple X-ray structures, but the structure of an adenine complex is unknown. We examined the selectivity of predicted A<sub>1</sub>AR and A<sub>3</sub>AR adenine antagonists that incorporated known agonist affinity-enhancing <i>N</i> <sup>6</sup> and C2 substituents. Adenines with A<sub>1</sub>AR-favoring <i>N</i> <sup>6</sup>-alkyl, cycloalkyl and arylalkyl substitutions combined with an A<sub>3</sub>AR-favoring 2-((5-chl ...[more]