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Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI.

ABSTRACT: PURPOSE:Coronary endothelial function (CEF) reflects vascular health and conventional invasive CEF measures predict cardiovascular events. MRI can now noninvasively measure CEF by quantifying coronary artery cross-sectional area changes in response to isometric handgrip exercise, an endothelial-dependent stressor. Area changes (10 to 20% in healthy; 2 to -12% in impaired vessels) are only a few imaging voxels because of MRI's limited spatial resolution. Here, with numerical simulations and phantom studies, we test whether Fourier interpolation enables sub-pixel area measurement precision and determine the smallest detectable area change using spiral MRI. METHODS:In vivo coronary SNR with the currently used CEF protocol at 3T was measured in 7 subjects for subsequent in vitro work. Area measurements of circular vessels were simulated by varying partial volume, vessel diameter, voxel size, SNR, and Fourier interpolation factor. A phantom with precision-drilled holes (diameters 3-3.42?mm) was imaged 10 times with the current CEF protocol (voxel size, ?x?=?0.89?mm) and a high-resolution protocol (?x?=?0.6?mm) to determine precision, accuracy, and the smallest detectable area changes. RESULTS:In vivo coronary SNR ranged from 30-76. Eight-fold Fourier interpolation improved area measurement precision by a factor 6.5 and 4.9 in the simulations and phantom scans, respectively. The current CEF protocol can detect mean area changes of 4-5% for SNR above 30, and 3-3.5% for SNR above 40 with a higher-resolution protocol. CONCLUSION:Current CEF spiral MRI with in vivo SNR allows detection of a 4-5% area change and Fourier interpolation improves precision several-fold to sub-voxel dimensions.

SUBMITTER: Schar M

PROVIDER: S-EPMC6258280 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI.

Schär Michael M Soleimanifard Sahar S Bonanno Gabriele G Yerly Jérôme J Hays Allison G AG Weiss Robert G RG

Magnetic resonance in medicine 20180719 1

<h4>Purpose</h4>Coronary endothelial function (CEF) reflects vascular health and conventional invasive CEF measures predict cardiovascular events. MRI can now noninvasively measure CEF by quantifying coronary artery cross-sectional area changes in response to isometric handgrip exercise, an endothelial-dependent stressor. Area changes (10 to 20% in healthy; 2 to -12% in impaired vessels) are only a few imaging voxels because of MRI's limited spatial resolution. Here, with numerical simulations a ...[more]

PMID: 30024061

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Dataset Information

Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI.

Publications

Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI.

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