Ontology highlight
ABSTRACT:
SUBMITTER: Froberg JE
PROVIDER: S-EPMC6258728 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Froberg John E JE Pinter Stefan F SF Kriz Andrea J AJ Jégu Teddy T Lee Jeannie T JT
Nature communications 20181127 1
The mammalian inactive X-chromosome (Xi) is structurally distinct from all other chromosomes and serves as a model for how the 3D genome is organized. The Xi shows weakened topologically associated domains and is instead organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Their functional significance is presently unclear, though one study suggests that they permit Xi genes to escape silencing. Here, we find that megadomains do not precede Xist expression or ...[more]