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Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/?-catenin pathway.


ABSTRACT: BACKGROUND:Fabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention. METHODS:In a previous study, novel lanthanum phosphate (LaPO4)/chitosan (CS) scaffolds were prepared by distributing 40- to 60-nm LaPO4 nanoparticles throughout plate-like CS films. RESULTS:Interconnected three dimensional (3D) macropores within the scaffolds increased the scaffold osteoconductivity, thereby promoting cell adhesion and bone tissue in-growth. The LaPO4/CS scaffolds showed no obvious toxicity and accelerated bone generation in a rat cranial defect model. Notably, the element La in the scaffolds was found to promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through the Wnt/?-catenin signalling pathway and induced high expression of the osteogenesis-related genes alkaline phosphatase, osteocalcin and Collagen I (Col-I). Moreover, the LaPO4/CS scaffolds enhanced bone regeneration and collagen fibre deposition in rat critical-sized calvarial defect sites. CONCLUSION:The novel LaPO4/CS scaffolds provide an admirable and promising platform for the repair of bone defects.

SUBMITTER: Hu H 

PROVIDER: S-EPMC6263548 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/β-catenin pathway.

Hu Haoran H   Zhao Peipei P   Liu Jiayu J   Ke Qinfei Q   Zhang Changqing C   Guo Yaping Y   Ding Hao H  

Journal of nanobiotechnology 20181129 1


<h4>Background</h4>Fabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention.<h4>Methods</h4>In a previous study, novel lanthanum phosphate (LaPO<sub>4</sub>)/chitosan (CS) scaffolds were prepared by distributing 40- to 60-nm LaPO<sub>4</sub> nanoparticles throughout plate-like CS films.<h4>Results</h4>Interconnected three dimensional (3D) macropores within the scaffolds increased the scaffold osteoconductivi  ...[more]

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