Ontology highlight
ABSTRACT:
SUBMITTER: Bitoque DB
PROVIDER: S-EPMC7789810 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Bitoque Diogo B DB Morais Joana J Oliveira Ana V AV Sequeira Raquel L RL Calado Sofia M SM Fortunato Tiago M TM Simão Sónia S Rosa da Costa Ana M AM Silva Gabriela A GA
Bioscience reports 20210101 1
Nuclear import is considered as one of the major limitations for non-viral gene delivery systems and the incorporation of nuclear localization signals (NLS) that mediate nuclear intake can be used as a strategy to enhance internalization of exogenous DNA. In this work, human-derived endogenous NLS peptides based on insulin growth factor binding proteins (IGFBP), namely IGFBP-3 and IGFBP-5, were tested for their ability to improve nuclear translocation of genetic material by non-viral vectors. Se ...[more]