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The Kinase IKK? Regulates a STING- and NF-?B-Dependent Antiviral Response Pathway in Drosophila.

ABSTRACT: Antiviral immunity in Drosophila involves RNA interference and poorly characterized inducible responses. Here, we showed that two components of the IMD pathway, the kinase dIKK? and the transcription factor Relish, were required to control infection by two picorna-like viruses. We identified a set of genes induced by viral infection and regulated by dIKK? and Relish, which included an ortholog of STING. We showed that dSTING participated in the control of infection by picorna-like viruses, acting upstream of dIKK? to regulate expression of Nazo, an antiviral factor. Our data reveal an antiviral function for STING in an animal model devoid of interferons and suggest an evolutionarily ancient role for this molecule in antiviral immunity.

SUBMITTER: Goto A

PROVIDER: S-EPMC6267954 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.

Goto Akira A Okado Kiyoshi K Martins Nelson N Cai Hua H Barbier Vincent V Lamiable Olivier O Troxler Laurent L Santiago Estelle E Kuhn Lauriane L Paik Donggi D Silverman Neal N Holleufer Andreas A Hartmann Rune R Liu Jiyong J Peng Tao T Hoffmann Jules A JA Meignin Carine C Daeffler Laurent L Imler Jean-Luc JL

Immunity 20180814 2

Antiviral immunity in Drosophila involves RNA interference and poorly characterized inducible responses. Here, we showed that two components of the IMD pathway, the kinase dIKKβ and the transcription factor Relish, were required to control infection by two picorna-like viruses. We identified a set of genes induced by viral infection and regulated by dIKKβ and Relish, which included an ortholog of STING. We showed that dSTING participated in the control of infection by picorna-like viruses, actin ...[more]

PMID: 30119996

Dataset Information

The Kinase IKK? Regulates a STING- and NF-?B-Dependent Antiviral Response Pathway in Drosophila.

Publications

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.

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