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Spiculisporic acids B–D, three new ?-butenolide derivatives from a sea urchin-derived fungus Aspergillus sp. HDf2.

ABSTRACT: Three new γ-butenolide derivatives 1–3, named spiculisporic acids B–D, were isolated from the culture of Aspergillus sp. HDf2, a marine-derived fungus that resides in the sea urchin, Anthocidaris crassispina. The structures of 1–3 were elucidated on the basis of spectroscopic methods, including MS and 2D NMR techniques. Their in vitro cytotoxic activities against two cell lines (SGC-7901, human gastric adenocarcinoma and SPC-A-1, human lung adenocarcinoma) and inhibitory activities against Staphylococcus aureus ATCC 51650 were investigated.

SUBMITTER: Wang R

PROVIDER: S-EPMC6268229 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Spiculisporic acids B–D, three new γ-butenolide derivatives from a sea urchin-derived fungus Aspergillus sp. HDf2.

Wang Rong R Liu Tian-Mi TM Shen Ming-Hui MH Yang Ming-Qiu MQ Feng Quan-Ying QY Tang Xian-Ming XM Li Xiang-Min XM

Molecules (Basel, Switzerland) 20121105 11

Three new γ-butenolide derivatives 1–3, named spiculisporic acids B–D, were isolated from the culture of Aspergillus sp. HDf2, a marine-derived fungus that resides in the sea urchin, Anthocidaris crassispina. The structures of 1–3 were elucidated on the basis of spectroscopic methods, including MS and 2D NMR techniques. Their in vitro cytotoxic activities against two cell lines (SGC-7901, human gastric adenocarcinoma and SPC-A-1, human lung adenocarcinoma) and inhibitory a ...[more]

PMID: 23128094

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