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Butenolide Derivatives with ?-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10.

ABSTRACT: Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, and the absolute configurations of 1 and 2 were determined by comparisons of experimental electronic circular dichroism (ECD) with calculated ECD spectra. Compound 1 represents the rare example of Aspergillus-derived butenolide derivatives featured by a monosubstituted benzene ring. Compounds 6-9 exhibited remarkable inhibitory effects against ?-glucosidase with IC50 values of 3.87, 1.37, 6.98, and 8.06 ?M, respectively, being much more active than the positive control acarbose (190.2 ?M).

SUBMITTER: Cheng Z

PROVIDER: S-EPMC6627487 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Butenolide Derivatives with α-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10.

Cheng Zhongbin Z Li Yuanli Y Liu Wan W Liu Lijun L Liu Jie J Yuan Wangjun W Luo Zhuhua Z Xu Wei W Li Qin Q

Marine drugs 20190603 6

Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, and the absolute configurations of 1 and 2 were determined ...[more]

PMID: 31163670

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