Dataset Information
One-pot Ugi/Aza-Michael synthesis of highly substituted 2,5-diketopiperazines with anti-proliferative properties.
Ontology highlight
ABSTRACT:
SUBMITTER: Hartung A
PROVIDER: S-EPMC6268348 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
One-pot Ugi/Aza-Michael synthesis of highly substituted 2,5-diketopiperazines with anti-proliferative properties.
Molecules (Basel, Switzerland) 20121211 12
The well-known Ugi reaction of aldehydes with amines, carboxylic acids and isocyanides leads to the formation of acyclic α-acylaminocarboxamides. Replacement of the carboxylic acid derivatives with β-acyl substituted acrylic acids gives access to highly substituted 2,5-diketopiperazines in one single reaction-step without additives or complex reaction procedures. The obtained diketopiperazines show anti-proliferative effects on activated T cells and represent therefore potential candidates for t ...[more]