Dataset Information
Synthesis and biological evaluation of novel N-methyl-picolinamide-4-thiol derivatives as potential antitumor agents.
Ontology highlight
ABSTRACT:
SUBMITTER: Huang TT
PROVIDER: S-EPMC6268926 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Synthesis and biological evaluation of novel N-methyl-picolinamide-4-thiol derivatives as potential antitumor agents.
Molecules (Basel, Switzerland) 20120525 6
A novel series of N-methylpicolinamide-4-thiol derivatives were synthesized and evaluated on human cancer cell lines. Among them, compound 6p displayed potent and broad-spectrum anti-proliferative activities in vitro on some human cancer cell lines, even better than sorafenib. The advanced kinase inhibitory assays showed that compound 6p could selectively inhibit Aurora-B kinase. The biological results were rationalized by the molecular docking study, which indicated the stable interactions of 6 ...[more]